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Photo 1 of 46: 109 E Calhoun St
109 E Calhoun St
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110 E Greenville Street, Anderson, SC 29621

Anderson County

Key Facts

1.21Lot (acres)
1Stories

Description

Endless investment potential on one of Anderson's most iconic corners! Nestled in one of Anderson’s most prominent and well-trafficked locations, this multi-building, multi-tenant portfolio property offers an unparalleled opportunity for business owners and investors alike. Occupying nearly half of one of the city’s most iconic blocks, this property is a cornerstone of Anderson’s bustling commercial hub. Its strategic location at the intersection of E Greenville Street and Main Street ensures maximum visibility and accessibility, making it an ideal destination for retail, professional services, or dining establishments. Spanning 1.21 acres with over 14,000 square feet of versatile space, the property features multiple buildings designed to accommodate a range of commercial needs. Positioned at the corner of E Calhoun and McDuffie Streets, the site also enjoys frontage along E Greenville Street, with red-light access on three sides to ensure seamless traffic flow for patrons and clients. The property’s layout offers flexibility, allowing tenants to customize the spaces to suit their specific requirements, whether they are a retail vendor, restaurateur, or professional office provider. The visibility and accessibility of this property are unmatched. Its location within the heart of Anderson places it amidst thriving businesses, providing a steady stream of potential customers. The property’s position on key city streets ensures consistent exposure to both pedestrian and vehicle traffic, making it a highly desirable site for a range of ventures. Whether you’re looking to establish a flagship retail store, expand a professional office portfolio, or create a dining destination in one of South Carolina’s fastest-growing cities, this property offers the space, location, and flexibility needed to bring your vision to life. With its prime location and multi-tenant potential, this commercial listing is a rare opportunity to secure a presence in the heart of Anderson’s vibrant economic landscape. Don’t miss your chance to be part of this thriving community.

Property Information

Property Type

Commercial Sale

Sub-Type

Retail

Stories

1

Lot Size

1.21 acres

Days on Market

526

MLS® Listing#

20282299

Property Features

Exterior

Other

Cooling

Central AirElectric

Heating

Natural GasCentral

Flooring

CarpetConcreteVinyl

Lot Features

LevelCity Lot

Construction

Brick

Roof

Metal

Windows

Display Window(s)

Utilities

Cable AvailableElectricity AvailableNatural Gas AvailablePhone AvailableSewer AvailableWater Available

Water Source

Public

Financial Details

Annual Taxes

$13,100

Tax year 2024

Parcel Number

1232921003

Directions

Interstate 85 to exit 27 towards Anderson. Follow the 4 lane highway to main street and property will be on the left before red light.

Affordability Calculator

$460,000

Estimated monthly payment

$12,242/mo

Principal $1,840,000 · Est. interest $2,566,964 over 30 yrs

Neighborhood Market Statistics

How this home compares to active listings in Anderson, SC

$335,729
Median Listing Price
70
Median Days on Market
1,941
Median Sq Ft
$171
Median Price / Sq Ft
958
Active Listings
  • This home’s price is 585% above the area median.

Market statistics compiled from active EXIT Realty® and MLS listings in Anderson, SC.

Location

Map showing the location of 110 E Greenville Street, Anderson, SC 29621

Points of Interest in Anderson, SC

Showing the Anderson area map.

Nearby Schools

  • Presbyterian Church

    School · 0.4 mi away

  • Anderson County Alternative School

    School · 0.8 mi away

  • Anderson Adult Education Center

    School · 1.0 mi away

  • South Fant School of Early Education

    School · 1.5 mi away

  • St Joseph Catholic School

    Elementary · 1.6 mi away

  • McCants Middle School

    Secondary · 1.8 mi away

  • Concord Elementary School

    Elementary · 1.9 mi away

  • Oakwood Baptist Church

    School · 1.9 mi away

  • Lakeside Middle School of Inquiry and Innovation A Stems School

    Elementary · 2.0 mi away

  • Anderson Institute of Technology

    Secondary School · 2.0 mi away

  • West Market Early Childhood

    School · 2.0 mi away

  • Anderson County School District 5

    School · 2.1 mi away

  • Whitehall Elementary School

    Elementary · 2.2 mi away

  • Westside High School

    Secondary · 2.3 mi away

  • New Covenant School

    School · 2.4 mi away

  • Robert Anderson Middle School

    Secondary · 2.4 mi away

  • Nevitt Forest Elementary School

    Elementary · 3.0 mi away

  • New Prospect Elementary School

    Elementary · 3.1 mi away

  • Homeland Park Primary

    Elementary · 3.3 mi away

  • Varennes Elementary School

    Elementary · 3.3 mi away

Commute Calculator

Travel mode

Nearby Homes

Similar Homes Nearby

Similar Home Values

Comparable nearby listings and their asking prices.

AddressPriceBedsBathsSq Ft
622 Jackson Road, Anderson, SC$1,699,900454,952
622 Jackson Road, Anderson, SC$1,699,900454,952
316 Green Hill Drive, Anderson, SC$1,750,000556,300
0 Hwy 29 Highway, Anderson, SC$1,800,000
1214 Sunset Lane, Anderson, SC$1,800,000434,500
2406, 2408, 2410 N Main Street, Anderson, SC$1,990,000

Moving Cost Estimate

EXIT Agents in Anderson

Listing Courtesy: Howard Hanna Allen Tate/Pine to Palm Realty - 8642937000

Presented by: Sherry Traynum

This information is deemed reliable, but not guaranteed. Neither the Western Upstate Association of REALTORS® , Inc. or Western Upstate Multiple Listing Service of South Carolina, Inc., nor the listing broker, nor their agents or subagents are responsible for the accuracy of the information. The buyer is responsible for verifying all information. This information is provided by the Western Upstate Association of REALTORS® , Inc. and Western Upstate Multiple Listing Service of South Carolina, Inc. for use by its members and is not intended for the use for any other purpose. Copyright ©2026 Western Upstate Association of REALTORS®, Inc. All Rights Reserved.

The data relating to real estate for sale on this web site comes in part from the Internet Data Exchange (IDX) program of one or more Multiple Listing Services (MLS). Listing information is deemed reliable but is not guaranteed accurate. Copyright © EXIT Realty® and respective MLS providers.

Data provided by WesternUpstateAssociationOfRealtors. MLS® Listing#20282299. © 2026EXIT Realty®. All rights reserved.